class ii gene การใช้

• This protein binds to the Xboxes of MHC class II genes and is essential for their expression.
• The Mediator complex is required for the successful transcription of nearly all class II gene promoters in yeast.
• The mediator complex is required for the successful transcription of nearly all class II gene promoters in yeast.
• "' Mediator "'is a multiprotein complex that functions as a transcriptional transcription of nearly all class II gene promoters in yeast.
• These developments alerted immunologists on the one hand and transplantation biologists on the other of the linked to the class I or class II genes to function properly.
• The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro.
• The RFX proteins were originally cloned and characterized due to their high affinity for a cis-acting promoter sequence, called the Xbox, found in all MHC class II genes.
• The discovery of the class II genes had been fitted into the model by the demonstration that they mapped between the " H2K " and the " H2D ".
• Type 1 diabetes markers associated with disease susceptibility have been identified, for example HLA class II gene variants, however possession of one or more of these genomic markers does not necessarily lead to disease.
• Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression.
• MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes.
• MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes.
• The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription.
• The two genes are thus unrelated to each other and to the class I and class II genes, but they are accidentally hooked together into a module, which has been found to duplicate or triplicate as a unit during primate evolution.
• Thus, for example, they showed that in each of the three major primate lineages  the prosimians, the NWM and the OWM  evolution of some of the class II gene families started anew after a contraction to a single ancestral gene.
• The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II . The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.
• Later, Klein s view received a strong support when his group discovered that in the fishes, which comprise more than half of jawed vertebrates, not even the class I and class II genes were in a single cluster and the class III genes were scattered all over the genome.